# Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Source: https://onco.cc/trials/nct05358249/  
OnCo record `nct05358249` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of JDQ443, Trametinib, Ribociclib in non-small-cell lung cancer and small-cell lung cancer, run by Novartis Pharmaceuticals, active and no longer recruiting.

## Summary

Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation is a phase 1/2 interventional study registered as NCT05358249 by Novartis Pharmaceuticals, with 74 participants enrolled, started 2022-10-24 and due to reach its primary completion in 2026-09-30. Interventions recorded: JDQ443, trametinib, Ribociclib, cetuximab. Conditions listed: KRAS G12C Mutant Solid Tumors, Carcinoma, Non-Small Cell Lung, Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05358249
- Phase: 1/2
- Setting: KontRASt-03: A Phase Ib/II, Multicenter, Open-label Platform Study of JDQ443 With Select Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
- Sponsor: Novartis Pharmaceuticals
- Enrolled: 74

## Sources

- ClinicalTrials.gov NCT05358249: https://clinicaltrials.gov/study/NCT05358249

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Cetuximab](https://onco.cc/drugs/cetuximab/), [JDQ443](https://onco.cc/drugs/jdq443/), [Ribociclib](https://onco.cc/drugs/ribociclib/), [Trametinib](https://onco.cc/drugs/trametinib/)
- companies: [Novartis](https://onco.cc/companies/novartis/)

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JSON: https://onco.cc/api/v1/entities/nct05358249.json