# Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer

Source: https://onco.cc/trials/nct05364489/  
OnCo record `nct05364489` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of bevacizumab (glioblastoma use), fOLFOX (5-FU, leucovorin, oxaliplatin) and trifluridine/tipiracil in colorectal cancer, run by The First Affiliated Hospital of Zhengzhou University, not yet recruiting.

## Summary

Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer is a phase 2, interventional study registered as NCT05364489 by The First Affiliated Hospital of Zhengzhou University, with a registry enrolment figure of 20 participants, started 2022-06-15 and due to reach its primary completion in 2025-06-15. Interventions recorded: Bevacizumab combined with Oxaliplatin and TAS-102. Conditions listed: Advanced Colorectal Cancer. Primary outcome: Progression Free Survival (PFS). Colorectal eligibility wording from the registry: "advanced colorectal cancer patients". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05364489
- Phase: 2
- Setting: Efficacy, Safety and Exploratory Clinical Study of Bevacizumab Combined With Oxaliplatin and TAS-102 in First-line Treatment of Advanced Colorectal Cancer
- Sponsor: The First Affiliated Hospital of Zhengzhou University
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT05364489: https://clinicaltrials.gov/study/NCT05364489

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Trifluridine/tipiracil](https://onco.cc/drugs/trifluridine-tipiracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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