# Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05378919/  
OnCo record `nct05378919` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fluorouracil (5-FU) in colorectal cancer, run by Lithuanian University of Health Sciences, now recruiting.

## Summary

Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05378919 by Lithuanian University of Health Sciences, with a registry enrolment figure of 250 participants, started 2015-06-01 and due to reach its primary completion in 2025-06-01. Interventions recorded: Radiotherapy 50 Gy; Fluorouracil/folic acid; Chemotherapy in regimen with Oxaliplatin, fluorouracil, folinic acid (FOLFOX4); Radiotherapy 50 Gy. Conditions listed: Neoadjuvant Therapy in Rectal Cancer, Radiotherapy, FOLFOX. Primary outcome: disease-free survival. Colorectal eligibility wording from the registry: "* diagnosed with rectal adenocarcinoma;". Sites: Lithuania. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: RECTUM2015
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05378919
- Phase: 2
- Setting: Evaluation and Comparison of the Efficacy of a New Standard Pre-operative Chemotherapy for Stage II and III Colorectal Cancer According to the FOLFOX4 Regimen With Routine Chemoradiation Therapy
- Sponsor: Lithuanian University of Health Sciences
- Enrolled: 250

## Sources

- ClinicalTrials.gov NCT05378919: https://clinicaltrials.gov/study/NCT05378919

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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