# A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct05379595/  
OnCo record `nct05379595` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Amivantamab, Fluorouracil, FLOT in colorectal cancer, run by Janssen Research & Development, LLC, now recruiting.

## Summary

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer is a phase 1/2 interventional study registered as NCT05379595 by Janssen Research & Development, LLC, with 225 participants planned, started 2022-07-29 and due to reach its primary completion in 2027-04-27. Interventions recorded: Amivantamab IV, Fluorouracil, Leucovorin, Oxaliplatin, Irinotecan. Conditions listed: Advanced or Metastatic Colorectal Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05379595
- Phase: 1/2
- Setting: A Phase 1b/2, Open-Label Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
- Sponsor: Janssen Research & Development, LLC
- Enrolled: 225

## Sources

- ClinicalTrials.gov NCT05379595: https://clinicaltrials.gov/study/NCT05379595

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- drugs: [Amivantamab](https://onco.cc/drugs/amivantamab/), [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)](https://onco.cc/drugs/flot/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/)
- companies: [Johnson & Johnson](https://onco.cc/companies/johnson-johnson/)

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