# A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

Source: https://onco.cc/trials/nct05382338/  
OnCo record `nct05382338` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Cisplatin, Cyclophosphamide, Lomustine, Sodium thiosulfate and Vincristine in Medulloblastoma, run by Children's Oncology Group, now recruiting.

## Summary

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss is a phase 3 interventional study registered as NCT05382338 by Children's Oncology Group, with 225 participants planned, started 2023-02-20 and due to reach its primary completion in 2029-12-31. Interventions recorded: Audiometric Test, Auditory Brainstem Response, Biospecimen Collection, Cisplatin, Cyclophosphamide, Lomustine, Magnetic Resonance Imaging, Quality-of-Life Assessment, Radiation Therapy, Sodium Thiosulfate, Survey Administration, Vincristine. Conditions recorded: Childhood Medulloblastoma.

Linked to the drug Sodium thiosulfate because the registry names it among its interventions and Medulloblastoma among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05382338
- Phase: 3
- Setting: A Phase 3 Study of Sodium Thiosulfate for Reduction of Cisplatin-Induced Ototoxicity in Children With Average-Risk Medulloblastoma and Reduced Therapy in Children With Medulloblastoma With Low-Risk Features
- Sponsor: Children's Oncology Group
- Enrolled: 225

## Sources

- ClinicalTrials.gov NCT05382338: https://clinicaltrials.gov/study/NCT05382338

## Connected records

- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/)
- drugs: [Cisplatin](https://onco.cc/drugs/cisplatin/), [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Lomustine (CCNU)](https://onco.cc/drugs/lomustine/), [Sodium thiosulfate (otoprotectant)](https://onco.cc/drugs/sodium-thiosulfate/), [Vincristine](https://onco.cc/drugs/vincristine/)

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