# A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Source: https://onco.cc/trials/nct05411718/  
OnCo record `nct05411718` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of aspirin in colorectal cancer, run by M.D. Anderson Cancer Center, now recruiting.

## Summary

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome is a phase 2, randomised interventional study registered as NCT05411718 by M.D. Anderson Cancer Center, with a registry enrolment figure of 40 participants, started 2023-03-21 and due to reach its primary completion in 2026-11-30. Interventions recorded: Naproxen; Aspirin. Conditions listed: T Cells; Colorectal Cancer; Lynch Syndrome. Primary outcome: To establish the effect of naproxen or aspirin on the abundance of T cells and other immune. Colorectal eligibility wording from the registry: "* Participants must be at least 6 months from any prior cancer-directed treatment (such as surgical resection, chemotherapy, immunotherapy, hormonal therapy or radiation)". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05411718
- Phase: 2
- Setting: A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome
- Sponsor: M.D. Anderson Cancer Center
- Enrolled: 40

## Sources

- ClinicalTrials.gov NCT05411718: https://clinicaltrials.gov/study/NCT05411718

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Aspirin](https://onco.cc/drugs/aspirin/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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