# Adjuvant mFOLFOXIRI vs. mFOLFOX6 in MRD Positive Stage II-III Colorectal Cancer (AFFORD)

Source: https://onco.cc/trials/nct05427669/  
OnCo record `nct05427669` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of FOLFOXIRI and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Yanhong Deng, not yet recruiting.

## Summary

Adjuvant mFOLFOXIRI vs. mFOLFOX6 in MRD Positive Stage II-III Colorectal Cancer (AFFORD) is a phase 3, randomised interventional study registered as NCT05427669 by Yanhong Deng, with a registry enrolment figure of 340 participants, started 2022-10-09 and due to reach its primary completion in 2025-07-01. Interventions recorded: mFOLFOXIRI; mFOLFOX6. Conditions listed: Colorectal Cancer. Primary outcome: 3-year Disease-free Survival (DFS). Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the colon or rectum". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: AFFORD
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05427669
- Phase: 3
- Setting: Adjuvant Modified FOLFOXIRI Versus mFOLFOX6 in Patients With Postoperative MRD Positive Stage II-III Colorectal Cancer: A Multicenter, Open Lable Randomized Phase 3 Study (AFFORD)
- Sponsor: Yanhong Deng
- Enrolled: 340

## Sources

- ClinicalTrials.gov NCT05427669: https://clinicaltrials.gov/study/NCT05427669

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)](https://onco.cc/drugs/folfoxiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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