# Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations

Source: https://onco.cc/trials/nct05445791/  
OnCo record `nct05445791` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Instituto Nacional de Cancerologia de Mexico, now recruiting.

## Summary

Metformin Plus Tyrosine Kinase Inhibitors for Treatment of Patients With Non-small Cell Lung Cancer With EGFR Mutations is a phase 3, randomised interventional study registered as NCT05445791 by Instituto Nacional de Cancerologia de Mexico, with a registry enrolment figure of 312 participants, started 2021-07-15 and due to reach its primary completion in 2026-07-14. Interventions recorded: Metformin Hydrochloride; Placebo. Conditions listed: Non Small Cell Lung Cancer. Primary outcome: Progression-free survival. Lung eligibility wording from the registry: "Patients with a histologically confirmed diagnosis of non-small cell lung cancer (stage IIIB-IV) according to the American Joint Committee on Cancer (AJCC) eight edition". Sites: Mexico. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: METLUNG
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT05445791
- Phase: 3
- Setting: Effect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone for Patients With Advanced Non-small Cell Lung Cancer and EGFR Mutations: Phase 3 Randomized Clinical Trial
- Sponsor: Instituto Nacional de Cancerologia de Mexico
- Enrolled: 312

## Sources

- ClinicalTrials.gov NCT05445791: https://clinicaltrials.gov/study/NCT05445791

## Connected records

- cancers: [EGFR-mutated non-small-cell lung cancer](https://onco.cc/cancers/egfr-mutant-nsclc/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05445791.json