# Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILS

Source: https://onco.cc/trials/nct05451784/  
OnCo record `nct05451784` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in triple-negative breast cancer, run by Fundacio Clinic Barcelona, now recruiting.

## Summary

Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ TILS is a phase 1/2, interventional study registered as NCT05451784 by Fundacio Clinic Barcelona, with a registry enrolment figure of 20 participants, started 2022-07-20 and due to reach its primary completion in 2025-11-30. Interventions recorded: PD1+ TILs (NUMARZU-001) product infusion. Conditions listed: Metastatic Triple-Negative Breast Carcinoma. Triple-negative eligibility wording from the registry: "Histologically confirmed diagnosis of advanced triple-negative breast cancer (based on the most recently analyzed biopsy from locally recurrent or metastatic site, local laboratory) meeting the following criteria: HER2-negative in situ hybridization test or an immunohistochemistry (IHC) status of 0 ". Sites: Spain. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: TILS001
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT05451784
- Phase: 1/2
- Setting: Treatment of Advanced or Metastatic Triple-negative Breast Cancer With Adoptive Therapy of PD1+ Tumor-infiltrating Lymphocytes (TILS001 Trial)
- Sponsor: Fundacio Clinic Barcelona
- Enrolled: 20

## Sources

- ClinicalTrials.gov NCT05451784: https://clinicaltrials.gov/study/NCT05451784

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05451784.json