# Neoadjuvant Chemoradiotherapy Combined With Tislelizumab in the Treatment of Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05479240/  
OnCo record `nct05479240` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of tislelizumab, capecitabine and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Fujian Cancer Hospital, not yet recruiting.

## Summary

Neoadjuvant Chemoradiotherapy Combined With Tislelizumab in the Treatment of Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05479240 by Fujian Cancer Hospital, with a registry enrolment figure of 94 participants, started 2023-09-01 and due to reach its primary completion in 2025-06-01. Interventions recorded: Tislelizumab; Capecitabine; oxaliplatin; short-range radiotherapy. Conditions listed: Immunotherapy. Primary outcome: Pathological complete response rate. Colorectal eligibility wording from the registry: "* Rectal adenocarcinoma confirmed by histopathology;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05479240
- Phase: 2
- Setting: Neoadjuvant Chemoradiotherapy Combined With Tislelizumab in the Treatment of Locally Advanced Rectal Cancer--Randomized, Open, Multicenter Clinical Study
- Sponsor: Fujian Cancer Hospital
- Enrolled: 94

## Sources

- ClinicalTrials.gov NCT05479240: https://clinicaltrials.gov/study/NCT05479240

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Tislelizumab](https://onco.cc/drugs/tislelizumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05479240.json