# Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05484024/  
OnCo record `nct05484024` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of sintilimab in colorectal cancer, run by Chinese Academy of Medical Sciences, not yet recruiting.

## Summary

Short-course Radiotherapy Followed by Chemotherapy and PD-1 Inhibitor for Locally Advanced Rectal Cancer is a phase 2/3, randomised interventional study registered as NCT05484024 by Chinese Academy of Medical Sciences, with a registry enrolment figure of 588 participants, started 2022-08-06 and due to reach its primary completion in 2028-07-31. Interventions recorded: Sintilimab; Short-course radiotherapy; CAPOX/mFOLFOX. Conditions listed: Rectal Neoplasms Malignant; Radiotherapy. Primary outcome: complete remission; Disease-free survival rate. Colorectal eligibility wording from the registry: "* Biopsy proven rectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05484024
- Phase: 2/3
- Setting: Preoperative Short-course Radiotherapy Followed by Chemotherapy With or Without PD-1 Inhibitor for Locally Advanced Rectal Cancer: a Prospective, Multicenter, Randomized Controlled, Phase II/III Study (STELLAR II Study)
- Sponsor: Chinese Academy of Medical Sciences
- Enrolled: 588

## Sources

- ClinicalTrials.gov NCT05484024: https://clinicaltrials.gov/study/NCT05484024

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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