# Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer

Source: https://onco.cc/trials/nct05491083/  
OnCo record `nct05491083` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in triple-negative breast cancer, run by National University Hospital, Singapore, now recruiting.

## Summary

Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer is a phase 1/2, interventional study registered as NCT05491083 by National University Hospital, Singapore, with a registry enrolment figure of 51 participants, started 2023-06-12 and due to reach its primary completion in 2026-12-31. Interventions recorded: Pembrolizumab & ADG106 (Phase Ib); Pembrolizumab & ADG106 (Phase II). Conditions listed: Advanced Solid Tumor; Triple Negative Breast Cancer. Triple-negative eligibility wording from the registry: "* Patients with histologically or cytologically confirmed TNBC, defined by expression of estrogen (ER) and progesterone receptors (PR) of \<1% and HER2 IHC score of 0 or 1+ or HER2 IHC score of 2+ but HER2 FISH negative". Sites: Singapore. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ComPACT
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT05491083
- Phase: 1/2
- Setting: A Phase 1b Followed by Phase II Expansion Trial of Combination of Pembrolizumab and ADG106 in Advanced Solid Cancers and Triple Negative Breast Cancer (ComPACT)
- Sponsor: National University Hospital, Singapore
- Enrolled: 51

## Sources

- ClinicalTrials.gov NCT05491083: https://clinicaltrials.gov/study/NCT05491083

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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