# Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer

Source: https://onco.cc/trials/nct05522660/  
OnCo record `nct05522660` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by ETOP IBCSG Partners Foundation, now recruiting.

## Summary

Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT05522660 by ETOP IBCSG Partners Foundation, with a registry enrolment figure of 180 participants, started 2022-11-30 and due to reach its primary completion in 2026-09. Interventions recorded: Stereotactic radiosurgery; Immune checkpoint inhibitor. Conditions listed: Non-Small Cell Lung Cancer; Melanoma. Primary outcome: CNS-specific PFS, locally assessed as per iRANO criteria. Lung eligibility wording from the registry: "* Primary disease of histologically confirmed (from primary tumour or from a metastatic lesion, including in the brain) melanoma or NSCLC". Sites: Italy, Netherlands, Spain, Switzerland, United Kingdom. United Kingdom sites listed: 2. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: USZ-STRIKE
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT05522660
- Phase: 3
- Setting: A Multicentre Randomised Open-label Phase III Study of Stereotactic Radiosurgery, in Addition to Standard Systemic Therapy for Patients With Metastatic Melanoma or Newly Diagnosed Metastatic NSCLC and Asymptomatic or Oligo-symptomatic Brain Metastases
- Sponsor: ETOP IBCSG Partners Foundation
- Enrolled: 180

## Notes

- UK sites (registry): Royal Marsden (Sutton) (London); Christie NHS Manchester (Manchester).

## Sources

- ClinicalTrials.gov NCT05522660: https://clinicaltrials.gov/study/NCT05522660

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- companies: [ETOP IBCSG Partners Foundation](https://onco.cc/companies/etop-ibcsg/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct05522660.json