# A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer

Source: https://onco.cc/trials/nct05587296/  
OnCo record `nct05587296` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Elinzanetant (BAY3427080) in HR-positive / HER2-negative breast cancer, run by Bayer, active and no longer recruiting.

## Summary

A Study to Learn More About How Well Elinzanetant Works and How Safe it is Compared to Placebo for the Treatment of Hot Flashes Caused by Anti-cancer Therapy in Women With, or at High Risk for Developing Hormone-receptor Positive Breast Cancer is a phase 3 interventional study registered as NCT05587296 by Bayer, with 474 participants enrolled, started 2022-10-14 and due to reach its primary completion in 2024-01-29. Interventions recorded: Elinzanetant (BAY3427080) and Placebo. Results have been posted on the registry.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05587296
- Phase: 3
- Setting: A Double-blind, Randomized, Placebo-controlled Multicenter Study to Investigate Efficacy and Safety of Elinzanetant for the Treatment of Vasomotor Symptoms Induced by Adjuvant Endocrine Therapy, Over 52 Weeks and Optionally for an Additional up to 3.5 Years in Women With Hormone-receptor Positive Breast Cancer:
- Sponsor: Bayer
- Enrolled: 474

## Sources

- ClinicalTrials.gov NCT05587296: https://clinicaltrials.gov/study/NCT05587296

## Connected records

- cancers: [HR-positive / HER2-negative breast cancer](https://onco.cc/cancers/breast-hr-positive/)
- companies: [Bayer](https://onco.cc/companies/bayer/)

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JSON: https://onco.cc/api/v1/entities/nct05587296.json