# A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

Source: https://onco.cc/trials/nct05592626/  
OnCo record `nct05592626` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of FOLFIRI, Irinotecan, Docetaxel in non-small-cell lung cancer and small-cell lung cancer, run by Marengo Therapeutics, Inc., now recruiting.

## Summary

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05592626 by Marengo Therapeutics, Inc., with 366 participants planned, started 2023-01-04 and due to reach its primary completion in 2027-09. Interventions recorded: STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere). Conditions listed: Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05592626
- Phase: 1/2
- Setting: A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule, in Subjects With Unresectable, Locally Advanced, or Metastatic Solid Tumors That Are Antigen-rich (START-001)
- Sponsor: Marengo Therapeutics, Inc.
- Enrolled: 366

## Sources

- ClinicalTrials.gov NCT05592626: https://clinicaltrials.gov/study/NCT05592626

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Docetaxel](https://onco.cc/drugs/docetaxel/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [Irinotecan (and liposomal irinotecan)](https://onco.cc/drugs/irinotecan/)
- companies: [Marengo Therapeutics](https://onco.cc/companies/marengo-therapeutics/)

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