# TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05646511/  
OnCo record `nct05646511` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by National Cancer Center Hospital East, now recruiting.

## Summary

TNT of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT05646511 by National Cancer Center Hospital East, with a registry enrolment figure of 608 participants, started 2022-11-21 and due to reach its primary completion in 2029-12-31. Interventions recorded: SCRT; CAPOX; CAPOXIRI. Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: Organ-preservation adapted DFS. Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma". Sites: Japan. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ENSEMBLE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05646511
- Phase: 3
- Setting: A Multicenter Randomized Phase III Study of Short-term Radiotherapy Plus CAPOX and Short-term Radiotherapy Plus CAPOXIRI as Preoperative Treatment for Locally Advanced Rectal Cancer
- Sponsor: National Cancer Center Hospital East
- Enrolled: 608

## Sources

- ClinicalTrials.gov NCT05646511: https://clinicaltrials.gov/study/NCT05646511

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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