# Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC)

Source: https://onco.cc/trials/nct05660083/  
OnCo record `nct05660083` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in triple-negative breast cancer, run by The Methodist Hospital Research Institute, now recruiting.

## Summary

Alpelisib/iNOS Inhibitor/Nab-paclitaxel in Patients With HER2 Negative Metaplastic Breast Cancer (MpBC) is a phase 2, interventional study registered as NCT05660083 by The Methodist Hospital Research Institute, with a registry enrolment figure of 36 participants, started 2023-01-12 and due to reach its primary completion in 2026-12-01. Interventions recorded: L-NMMA. Conditions listed: HER2-negative Breast Cancer; Metastatic Breast Cancer; Metaplastic Breast Carcinoma; TNBC - Triple-Negative Breast Cancer. Triple-negative eligibility wording from the registry: "Histologically confirmed HER2 negative MpBC and/or Triple Negative Breast Cancer (TNBC) with squamous and/or sarcomatoid elements, including osseous, chondroid, and spindle morphology". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT05660083
- Phase: 2
- Setting: Phase II Trial of Alpelisib With iNOS Inhibitor and Nab-paclitaxel in Patients With HER2 Negative Metastatic or Locally Advanced Metaplastic Breast Cancer (MpBC)
- Sponsor: The Methodist Hospital Research Institute
- Enrolled: 36

## Sources

- ClinicalTrials.gov NCT05660083: https://clinicaltrials.gov/study/NCT05660083

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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