# Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Source: https://onco.cc/trials/nct05673148/  
OnCo record `nct05673148` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Alliance for Clinical Trials in Oncology, now recruiting.

## Summary

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial is a phase 2, randomised interventional study registered as NCT05673148 by Alliance for Clinical Trials in Oncology, with a registry enrolment figure of 146 participants, started 2023-10-09 and due to reach its primary completion in 2028-07-03. Interventions recorded: Stereotactic Ablative Radiotherapy; Resection; Microwave Ablation; Chemotherapy; Computed Tomography; Magnetic Resonance Imaging; Positron Emission Tomography. Conditions listed: Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8; Oligometastatic Colorectal Carcinoma. Primary outcome: Overall Survival (OS). Colorectal eligibility wording from the registry: "* PRE-REGISTRATION (STEP 0): Pathologically proven diagnosis of metastatic colorectal adenocarcinoma with metastases (biopsy from primary tumor or metastatic site is acceptable)". Sites: Canada, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05673148
- Phase: 2
- Setting: A Pragmatic Randomized Phase II Trial Evaluating Total Ablative Therapy for Patients With Limited Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)
- Sponsor: Alliance for Clinical Trials in Oncology
- Enrolled: 146

## Sources

- ClinicalTrials.gov NCT05673148: https://clinicaltrials.gov/study/NCT05673148

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/), [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/)
- companies: [Alliance for Clinical Trials in Oncology](https://onco.cc/companies/alliance-oncology/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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