# COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER

Source: https://onco.cc/trials/nct05692024/  
OnCo record `nct05692024` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by Massachusetts General Hospital, now recruiting.

## Summary

COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER is a phase 1/2, randomised interventional study registered as NCT05692024 by Massachusetts General Hospital, with a registry enrolment figure of 80 participants, started 2024-03-21 and due to reach its primary completion in 2028-03-31. Interventions recorded: Nestlé NESCAFÉ® TASTER'S CHOICE® House Blend capsule.; Placebo. Conditions listed: Colorectal Cancer; Coffee; Gastrointestinal Microbiome; Stenosis; Fibrosis, Liver; Ultrasound Elastography; Proton Magnetic Resonance Spectroscopy. Primary outcome: Change in hepatic fat fraction.. Colorectal eligibility wording from the registry: "* Participants must have histologically confirmed stage I, II, or III colon or rectal adenocarcinoma and have completed standard treatment (including surgery, chemotherapy and radiotherapy) at least 2 months ago". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: COMMENCER
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05692024
- Phase: 1/2
- Setting: COMMENCER: COffee and Metabolites Modulating the Gut MicrobiomE in Colorectal caNCER
- Sponsor: Massachusetts General Hospital
- Enrolled: 80

## Sources

- ClinicalTrials.gov NCT05692024: https://clinicaltrials.gov/study/NCT05692024

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05692024.json