# Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer

Source: https://onco.cc/trials/nct05706779/  
OnCo record `nct05706779` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cetuximab in colorectal cancer, run by Federation Francophone de Cancerologie Digestive, now recruiting.

## Summary

Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer is a phase 2, interventional study registered as NCT05706779 by Federation Francophone de Cancerologie Digestive, with a registry enrolment figure of 30 participants, started 2023-02-13 and due to reach its primary completion in 2026-12-30. Interventions recorded: Encorafenib Oral Capsule + Cetuximab. Conditions listed: Colorectal Cancer; BRAF V600E Mutation Positive. Primary outcome: To assess the rate of significant tumour regression (TRG 0 to 2 according to Ryan's modified score of the AJCC 2010). Colorectal eligibility wording from the registry: "* Adenocarcinoma of the colon or of the upper rectum (supra-peritoneal) considered operable and histologically confirmed, localised, mutated BRAF V600E determined in a biopsy specimen and resectable after CT-scan assessment". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NEORAF
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05706779
- Phase: 2
- Setting: Combination of Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With Braf v600e-mutates Localised Colon or Upper Rectum Cancer (Neoraf Study)
- Sponsor: Federation Francophone de Cancerologie Digestive
- Enrolled: 30

## Sources

- ClinicalTrials.gov NCT05706779: https://clinicaltrials.gov/study/NCT05706779

## Connected records

- cancers: [BRAF V600E-mutant colorectal cancer](https://onco.cc/cancers/braf-v600e-colorectal/), [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Monoclonal antibodies](https://onco.cc/technologies/monoclonal-antibody/)
- drugs: [Cetuximab](https://onco.cc/drugs/cetuximab/)
- companies: [Pierre Fabre](https://onco.cc/companies/pierre-fabre/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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