# Niraparib Added to Anti-PD-L1 Antibody Maintenance in SLFN11-positive, Extensive-disease SCLC

Source: https://onco.cc/trials/nct05718323/  
OnCo record `nct05718323` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of niraparib in lung cancer, run by ETOP IBCSG Partners Foundation, now recruiting.

## Summary

Niraparib Added to Anti-PD-L1 Antibody Maintenance in SLFN11-positive, Extensive-disease SCLC is a phase 2, interventional study registered as NCT05718323 by ETOP IBCSG Partners Foundation, with a registry enrolment figure of 44 participants, started 2023-12-20 and due to reach its primary completion in 2026-12. Interventions recorded: Niraparib. Conditions listed: SCLC,Extensive Stage; SLFN11-positive. Primary outcome: Progression-free survival (PFS) rate at 3 months by investigator assessment (according to RECIST v1.1). Lung eligibility wording from the registry: "* Histologically or cytologically confirmed ED-SCLC (stage IV according to the 8th TNM classification)". Sites: France, Germany, Italy, Spain, Switzerland. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: RAISE
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT05718323
- Phase: 2
- Setting: A Single-arm Phase II Trial of the Addition of Niraparib to Anti-PD-L1 Antibody Maintenance in Patients With SLFN11-positive, Extensive-disease Small Cell Lung Cancer.
- Sponsor: ETOP IBCSG Partners Foundation
- Enrolled: 44

## Sources

- ClinicalTrials.gov NCT05718323: https://clinicaltrials.gov/study/NCT05718323

## Connected records

- cancers: [Extensive-stage small-cell lung cancer](https://onco.cc/cancers/extensive-stage-sclc/)
- technologies: [PARP inhibitors](https://onco.cc/technologies/parp-inhibitor/)
- drugs: [Niraparib](https://onco.cc/drugs/niraparib/)
- companies: [ETOP IBCSG Partners Foundation](https://onco.cc/companies/etop-ibcsg/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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