# Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05731726/  
OnCo record `nct05731726` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of serplulimab, capecitabine, fOLFOX (5-FU, leucovorin, oxaliplatin) and celecoxib in colorectal cancer, run by Zhejiang University, now recruiting.

## Summary

Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT05731726 by Zhejiang University, with a registry enrolment figure of 50 participants, started 2023-02-22 and due to reach its primary completion in 2026-12-30. Interventions recorded: Serplulimab; Capecitabine; Oxaliplatin; Celecoxib. Conditions listed: pMMR; MSS; MSI-L; Locally Advanced Rectal Carcinoma. Primary outcome: Pathological complete response rates. Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the rectum". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05731726
- Phase: 2
- Setting: A Phase II Study to Explore the Neoadjuvant Treatment of Serplulimab Combined With CAPEOX + Celecoxib in the Treatment of Locally Advanced Rectal Cancer
- Sponsor: Zhejiang University
- Enrolled: 50

## Sources

- ClinicalTrials.gov NCT05731726: https://clinicaltrials.gov/study/NCT05731726

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [Celecoxib](https://onco.cc/drugs/celecoxib/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [Serplulimab](https://onco.cc/drugs/serplulimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05731726.json