# Propranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor Refractory Metastatic or Unresectable Triple Negative Breast Cancer

Source: https://onco.cc/trials/nct05741164/  
OnCo record `nct05741164` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Pembrolizumab and Propranolol in Breast cancer, run by Emory University, now recruiting.

## Summary

Propranolol and Pembrolizumab for Tumor Re-sensitization and Treatment of Patients With Checkpoint Inhibitor Refractory Metastatic or Unresectable Triple Negative Breast Cancer is a phase 2 interventional study registered as NCT05741164 by Emory University, with 37 participants planned, started 2024-09-01 and due to reach its primary completion in 2028-06-30. Interventions recorded: Biopsy, Biospecimen Collection, Computed Tomography, Pembrolizumab, Propranolol, Questionnaire Administration. Conditions recorded: Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Triple-Negative Breast Carcinoma, Refractory Triple-Negative Breast Carcinoma, Unresectable Triple-Negative Breast Carcinoma.

Linked to the drug Propranolol because the registry names it among its interventions and Breast cancer among its conditions. Registry record only: no result has been read by an editor.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-22
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05741164
- Phase: 2
- Setting: Impact of Beta-2 Adrenergic Blockade With Checkpoint Inhibition in Checkpoint Inhibitor Refractory Metastatic Triple Negative Breast Cancer
- Sponsor: Emory University
- Enrolled: 37

## Sources

- ClinicalTrials.gov NCT05741164: https://clinicaltrials.gov/study/NCT05741164

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Propranolol (Hemangeol)](https://onco.cc/drugs/propranolol-hemangeol/)

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