# A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation

Source: https://onco.cc/trials/nct05745740/  
OnCo record `nct05745740` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of pyrotinib in lung cancer, run by RemeGen Co., Ltd., not yet recruiting.

## Summary

A Study of RC48-ADC Combined With Pyrotinib For Treatment of Local Advanced or Metastasis NSCLC With HER2 Mutation is a phase 1/2, interventional study registered as NCT05745740 by RemeGen Co., Ltd., with a registry enrolment figure of 26 participants, started 2027-12-01 and due to reach its primary completion in 2027-12-01. Interventions recorded: RC48-ADC; Pyrotinib. Conditions listed: Non-small Cell Lung Cancer. Primary outcome: maximal tolerance dose (MTD) of RC48-ADC combined with Pyrotinib. Lung eligibility wording from the registry: "* According to UICC/AJCC 8th Edition, histologically and/or cytologically-confirmed, cannot be surgically removed, locally advanced or metastatic NSCLC". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT05745740
- Phase: 1/2
- Setting: An Open-label, Single-center, Phase Ib/II Study to Evaluate the Safety, Efficacy and Pharmacokinetics of RC48-ADC Combined With Pyrotinib in Local Advanced or Metastasis NSCLC With HER2 Mutation
- Sponsor: RemeGen Co., Ltd.
- Enrolled: 26

## Sources

- ClinicalTrials.gov NCT05745740: https://clinicaltrials.gov/study/NCT05745740

## Connected records

- cancers: [HER2-mutant non-small-cell lung cancer](https://onco.cc/cancers/her2-mutant-nsclc/)
- drugs: [Pyrotinib](https://onco.cc/drugs/pyrotinib/)
- companies: [RemeGen](https://onco.cc/companies/remegen/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05745740.json