# Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma

Source: https://onco.cc/trials/nct05752136/  
OnCo record `nct05752136` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of envafolimab in colorectal cancer, run by Sir Run Run Shaw Hospital, now recruiting.

## Summary

Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma is a phase 3, randomised interventional study registered as NCT05752136 by Sir Run Run Shaw Hospital, with a registry enrolment figure of 108 participants, started 2023-04-01 and due to reach its primary completion in 2026-11-01. Interventions recorded: Envafolimab. Conditions listed: Rectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: "Diagnosed by digital rectal examination, colonoscopy, and high-resolution MRI of the pelvis, the tumor is less than or equal to 12 cm from the anus". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05752136
- Phase: 3
- Setting: Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma: a Prospective, Multicenter, Randomized Controlled Study (PRECAM-R)
- Sponsor: Sir Run Run Shaw Hospital
- Enrolled: 108

## Sources

- ClinicalTrials.gov NCT05752136: https://clinicaltrials.gov/study/NCT05752136

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Envafolimab](https://onco.cc/drugs/envafolimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05752136.json