# ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer

Source: https://onco.cc/trials/nct05815082/  
OnCo record `nct05815082` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer is a phase 3, randomised interventional study registered as NCT05815082 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 490 participants, started 2023-02-20 and due to reach its primary completion in 2031-02-20. Interventions recorded: Colorectal cancer resection combined with liver metastasis resection.; FOLFOX chemotherapy regimen. Conditions listed: Colorectal Cancer; Liver Metastases; Circulating Tumor Cell; Chemotherapy Effect. Primary outcome: 3-year progression-free survival; 5-year progression-free survival. Colorectal eligibility wording from the registry: "Patients with liver metastatic colorectal cancer who have achieved R0 resection according to MDT evaluation (including patients with metastases treated with ablation therapy that achieved similar R0 resection effects);". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05815082
- Phase: 3
- Setting: ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer: A Prospective Multicenter Randomized Controlled Clinical Trial
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 490

## Sources

- ClinicalTrials.gov NCT05815082: https://clinicaltrials.gov/study/NCT05815082

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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