# Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers

Source: https://onco.cc/trials/nct05846789/  
OnCo record `nct05846789` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of tocilizumab in triple-negative breast cancer, run by Kathy Miller, now recruiting.

## Summary

Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers is a phase 2, randomised interventional study registered as NCT05846789 by Kathy Miller, with a registry enrolment figure of 168 participants, started 2024-07-02 and due to reach its primary completion in 2027-12. Interventions recorded: SOC Chemotherapy; Tocilizumab/Tocilizumab Biosimilar. Conditions listed: Metastatic Breast Cancer; Triple Negative Breast Cancer; Estrogen-receptor-low Breast Cancer; ER Positive, HER2 Negative Breast Cancer. Triple-negative eligibility wording from the registry: "Locally recurrent (not amenable to local therapy with curative intent) or metastatic breast cancer that is triple negative or ER-positive (ER and PR ≤ 1% weak staining)". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT05846789
- Phase: 2
- Setting: A Pragmatic Phase II Trial of Chemotherapy +/- Tocilizumab for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers
- Sponsor: Kathy Miller
- Enrolled: 168

## Sources

- ClinicalTrials.gov NCT05846789: https://clinicaltrials.gov/study/NCT05846789

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- drugs: [Tocilizumab](https://onco.cc/drugs/tocilizumab/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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