# A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer

Source: https://onco.cc/trials/nct05846867/  
OnCo record `nct05846867` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of AK119, Ivonescimab, CAPOX in colorectal cancer, run by Akeso, active and no longer recruiting.

## Summary

A Phase Ib/II Clinical Study on AK112 Combined or Not Combined With AK119 in pMMR/MSS Colorectal Cancer is a phase 1/2 interventional study registered as NCT05846867 by Akeso, with 170 participants planned, started 2023-05-08 and due to reach its primary completion in 2026-05-08. Interventions recorded: AK119, AK112, Oxaliplatin, Irinotecan, Calcium folinate. Conditions listed: Colorectal Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05846867
- Phase: 1/2
- Setting: An Open, Multicenter Phase Ib/II Clinical Study on the Efficacy and Safety of AK119 and AK112, Either in Combination or Not, With Chemotherapy, and AK112 Monotherapy in pMMR/MSS CRC
- Sponsor: Akeso
- Enrolled: 170

## Sources

- ClinicalTrials.gov NCT05846867: https://clinicaltrials.gov/study/NCT05846867

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- drugs: [AK119](https://onco.cc/drugs/ak119/), [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [Ivonescimab](https://onco.cc/drugs/ivonescimab/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)
- companies: [Akeso](https://onco.cc/companies/akeso/)

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JSON: https://onco.cc/api/v1/entities/nct05846867.json