# Study of AVZO-021 in Patients With Advanced Solid Tumors

Source: https://onco.cc/trials/nct05867251/  
OnCo record `nct05867251` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of AVZO-021, Palbociclib, Fulvestrant in ovarian cancer and endometrial cancer, run by Avenzo Therapeutics, Inc., now recruiting.

## Summary

Study of AVZO-021 in Patients With Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT05867251 by Avenzo Therapeutics, Inc., with 430 participants planned, started 2023-08-30 and due to reach its primary completion in 2028-01-31. Interventions recorded: AVZO-021, Palbociclib, Fulvestrant, Letrozole, Ribociclib. Conditions listed: Advanced Solid Tumor, HR+/HER2- Breast Cancer, HR+, HER2-, Advanced Breast Cancer, CCNE1 Amplification. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05867251
- Phase: 1/2
- Setting: A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-021 as a Single Agent and in Combination Therapy in Patients With Advanced Solid Tumors
- Sponsor: Avenzo Therapeutics, Inc.
- Enrolled: 430

## Sources

- ClinicalTrials.gov NCT05867251: https://clinicaltrials.gov/study/NCT05867251

## Connected records

- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- drugs: [Abemaciclib](https://onco.cc/drugs/abemaciclib/), [AVZO-021](https://onco.cc/drugs/avzo-021/), [Fulvestrant](https://onco.cc/drugs/fulvestrant/), [Letrozole (and other aromatase inhibitors)](https://onco.cc/drugs/letrozole/), [Palbociclib](https://onco.cc/drugs/palbociclib/), [Ribociclib](https://onco.cc/drugs/ribociclib/)
- companies: [Avenzo Therapeutics](https://onco.cc/companies/avenzo/)

---
JSON: https://onco.cc/api/v1/entities/nct05867251.json