# Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER

Source: https://onco.cc/trials/nct05870800/  
OnCo record `nct05870800` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Baylor College of Medicine, now recruiting.

## Summary

Phase II Open-label Trial of Neoadjuvant Immunochemotherapy for Resectable Non-metastatic Colon cancER: NICER is a phase 2, interventional study registered as NCT05870800 by Baylor College of Medicine, with a registry enrolment figure of 28 participants, started 2025-06-15 and due to reach its primary completion in 2026-09-01. Interventions recorded: Tecentriq 1200 MG in 20 ML Injection + Capecitabine 1000 mg/m2 + Oxaliplatin 130 mg/m2; Oxaliplatin injection 85mg/m2 + Leucovorin 400mg/m2 + 5-Fluorouracil 2400mg/m2; Oxaliplatin 130mg/m2 + Capecitabine 1000mg/m2. Conditions listed: Stage I Colon Cancer; Stage II Colon Cancer; Stage III Colon Cancer. Primary outcome: Determine the rate of tumor regression grade 1 (<10% viable cancer cells) to neoadjuvant immunotherapy and chemotherapy in resectable (non-metastatic) pMMR colon cancer, assessed in the resection specimen.. Colorectal eligibility wording from the registry: "* Histologically or cytologically confirmed resectable non-metastatic adenocarcinoma of the colon". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NICER
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05870800
- Phase: 2
- Setting: Phase II Open-label Trial of Neoadjuvant Immunotherapy (Atezolizumab) in Combination With CAPOX for Resectable Non-metastatic Proficient Mismatch Repair (pMMR) Colon CancER: NICER Study
- Sponsor: Baylor College of Medicine
- Enrolled: 28

## Sources

- ClinicalTrials.gov NCT05870800: https://clinicaltrials.gov/study/NCT05870800

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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