# Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer

Source: https://onco.cc/trials/nct05909423/  
OnCo record `nct05909423` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of pembrolizumab in colorectal cancer, run by Zealand University Hospital, not yet recruiting.

## Summary

Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer is a phase 2, interventional study registered as NCT05909423 by Zealand University Hospital, with a registry enrolment figure of 21 participants, started 2023-09-01 and due to reach its primary completion in 2025-09-01. Interventions recorded: Influenza vaccine; Pembrolizumab. Conditions listed: Colorectal Cancer. Primary outcome: Pathological response. Colorectal eligibility wording from the registry: "* Have histologically confirmed localized pMMR stage cT1N0M0 to cT4N2M0 (stage I to III) colorectal adenocarcinoma". Sites: Denmark. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: FLU-IMMUNE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05909423
- Phase: 2
- Setting: Combining Intratumoral Flu Vaccine and Systemic Pembrolizumab in Patients With Early pMMR Colorectal Cancer - the FLU-IMMUNE Trial.
- Sponsor: Zealand University Hospital
- Enrolled: 21

## Sources

- ClinicalTrials.gov NCT05909423: https://clinicaltrials.gov/study/NCT05909423

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Off-the-shelf cancer vaccines](https://onco.cc/technologies/shared-antigen-vaccine/)
- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct05909423.json