# Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer

Source: https://onco.cc/trials/nct05914389/  
OnCo record `nct05914389` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) and capecitabine in colorectal cancer, run by Second Affiliated Hospital, Zhejiang University, School of Medicine, now recruiting.

## Summary

Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer is a phase 2, randomised interventional study registered as NCT05914389 by Second Affiliated Hospital, Zhejiang University, School of Medicine, with a registry enrolment figure of 100 participants, started 2023-08 and due to reach its primary completion in 2025-08. Interventions recorded: Oxaliplatin; Capecitabine; Anti-PD-L1 Monoclonal Antibody; Clostridium butyricum; Colectomy. Conditions listed: Colon Neoplasm. Primary outcome: TRG0/1. Colorectal eligibility wording from the registry: "* Pathologically diagnosed MSS or pMMR-type colon adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: ICONIC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05914389
- Phase: 2
- Setting: Induction Chemotherapy Combined With Neoadjuvant Immunotherapy for MSS Colon Cancer: a Prospective Single-center Multi-arm Open-label Randomized Phase II Study
- Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT05914389: https://clinicaltrials.gov/study/NCT05914389

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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