# HTL0039732 in Participants With Advanced Solid Tumours

Source: https://onco.cc/trials/nct05944237/  
OnCo record `nct05944237` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by Cancer Research UK, now recruiting.

## Summary

HTL0039732 in Participants With Advanced Solid Tumours is a phase 1/2, interventional study registered as NCT05944237 by Cancer Research UK, with a registry enrolment figure of 150 participants, started 2023-07-13 and due to reach its primary completion in 2027-06. Interventions recorded: HTL0039732 Capsules; HTL0039732 Capsules and atezolizumab infusion. Conditions listed: Neoplasms; Prostatic Neoplasms, Castration-Resistant; Stomach Neoplasms; Esophageal Neoplasms; Head and Neck Neoplasms; Colorectal Neoplasms; Pancreatic Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Mesothelioma, Malignant; Uterine Cervical Neoplasms; Kidney Neoplasms; Sarcoma; Pheochromocytomas. Primary outcome: Maximum tolerated dose (MTD; Dose Escalation Phase); RP2D (Dose Escalation Phase); Number of Adverse Events (AEs) Related to HTL0039732 (Dose Escalation and Expansion Phase). Pancreatic eligibility wording from the registry: "\- Histologically proven advanced solid tumour where PGE2/EP4 signalling is believed to be more prevalent or significant (such as microsatellite stable colorectal cancer (MSS CRC), gastro-esophageal cancer, head and neck squamous cell carcinoma (HNSCC), mCRPC, pancreatic cancer, lung cancer, bladder". Sites: United Kingdom. United Kingdom sites listed: 5. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT05944237
- Phase: 1/2
- Setting: A Cancer Research UK Phase I/IIa Trial of HTL0039732, Given Orally as Monotherapy and in Combination With Immunotherapy or Other Approved Therapies in Participants With Advanced Solid Tumours
- Sponsor: Cancer Research UK
- Enrolled: 150

## Notes

- UK sites (registry): Addenbrooke's Hospital (Cambridge); Velindre Cancer Centre (Cardiff); Clatterbridge Cancer Centre (Liverpool); Guy's Hospital (London); The Christie Hospital (Manchester).

## Sources

- ClinicalTrials.gov NCT05944237: https://clinicaltrials.gov/study/NCT05944237

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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