# Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer

Source: https://onco.cc/trials/nct05954078/  
OnCo record `nct05954078` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer is a phase 3, randomised interventional study registered as NCT05954078 by Fudan University, with a registry enrolment figure of 340 participants, started 2023-08-01 and due to reach its primary completion in 2026-06. Interventions recorded: mFOLFIRINOX adjuvant chemotherapy; mFOLFOX6/XELOX adjuvant chemotherapy. Conditions listed: High-risk Stage II Colorectal Cancer; Stage III Colorectal Cancer; Circulating Tumor DNA Methylation. Primary outcome: ctDNA clearance rate. Colorectal eligibility wording from the registry: "Patients who have been histopathologically diagnosed with colorectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05954078
- Phase: 3
- Setting: Circulating Tumor DNA Methylation Guided Postoperative Adjuvant Chemotherapy for High-risk Stage II/III Colorectal Cancer: A Multicenter, Prospective, Randomized Controlled Cohort Study (FINE Trial)
- Sponsor: Fudan University
- Enrolled: 340

## Sources

- ClinicalTrials.gov NCT05954078: https://clinicaltrials.gov/study/NCT05954078

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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