# Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct05959356/  
OnCo record `nct05959356` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Cetuximab and Envafolimab Plus mFOLFOXIRI as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT05959356 by Sun Yat-sen University, with a registry enrolment figure of 198 participants, started 2023-11-09 and due to reach its primary completion in 2026-12-31. Interventions recorded: Cetuximab + Envafolimab + mFOLFOXIRI; Cetuximab + mFOLFOX6. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Progression free survival. Colorectal eligibility wording from the registry: "* Patients have histologically or cytologically confirmed RAS and BRAF wild-type, MSS metastatic colorectal adenocarcinoma (mCRC), excluding appendiceal and anal cancers". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CEIL
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05959356
- Phase: 2
- Setting: Cetuximab and Envafolimab Plus mFOLFOXIRI Versus Cetuximab Plus mFOLFOX6 as First-line Treatment for RAS/BRAF Wild-type, MSS, Unresectable Left-side Metastatic Colorectal Cancer: A Randomized Controlled Phase II Trial (CEIL)
- Sponsor: Sun Yat-sen University
- Enrolled: 198

## Sources

- ClinicalTrials.gov NCT05959356: https://clinicaltrials.gov/study/NCT05959356

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05959356.json