# Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy

Source: https://onco.cc/trials/nct05965531/  
OnCo record `nct05965531` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of trifluridine/tipiracil in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Treating Locally Advanced Rectal Cancer With TAS-102 Chemotherapy Plus Neoadjuvant Radiotherapy is a phase 2, interventional study registered as NCT05965531 by Sun Yat-sen University, with a registry enrolment figure of 65 participants, started 2024-01-01 and due to reach its primary completion in 2028-12-31. Interventions recorded: Trifluridine/Tipiracil; intensity-modulated radiotherapy. Conditions listed: Rectal Cancer. Primary outcome: Objective response rate. Colorectal eligibility wording from the registry: "* Pathologically diagnosed rectal adenocarcinoma via biopsy". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: TASLARC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05965531
- Phase: 2
- Setting: A Single-arm, Phase II Clinical Trial to Treat Locally Advanced, pMMR Rectal Cancer With Single-agent Trifluridine/Tipiracil Chemotherapy Plus Neoadjuvant Intensity-modulated Radiotherapy
- Sponsor: Sun Yat-sen University
- Enrolled: 65

## Sources

- ClinicalTrials.gov NCT05965531: https://clinicaltrials.gov/study/NCT05965531

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Trifluridine/tipiracil](https://onco.cc/drugs/trifluridine-tipiracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05965531.json