# Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer

Source: https://onco.cc/trials/nct05969847/  
OnCo record `nct05969847` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) and envafolimab in colorectal cancer, run by 池畔, not yet recruiting.

## Summary

Organ Preservation Following Enverolimab-based Total Neoadjuvant Therapy for Locally Advanced Very Low Rectal Cancer is a phase 2, interventional study registered as NCT05969847 by 池畔, with a registry enrolment figure of 72 participants, started 2023-08-15 and due to reach its primary completion in 2027-12-31. Interventions recorded: split-course hypofraction radiotherapy; CAPOX; Envafolimab; Local excision. Conditions listed: Rectal Cancer. Primary outcome: Organ preservation. Colorectal eligibility wording from the registry: "Histopathology confirmed the rectal adenocarcinoma,cT3-4N0 or cT1-4N1-2". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: TRACE-LE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05969847
- Phase: 2
- Setting: Total Neoadjuvant Therapy With Split-course Hypofraction Radiotherapy Combined With CAPOX and Envafolimab Followed by Local Excision for Locally Advanced Very Low Rectal Cancer: an Open-label, Single-arm, Multi-center, Phase II Trial
- Sponsor: 池畔
- Enrolled: 72

## Sources

- ClinicalTrials.gov NCT05969847: https://clinicaltrials.gov/study/NCT05969847

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [Envafolimab](https://onco.cc/drugs/envafolimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05969847.json