# KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct05985109/  
OnCo record `nct05985109` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of regorafenib in colorectal cancer, run by Peking University Cancer Hospital & Institute, now recruiting.

## Summary

KN 046 Plus Regorafenib in MSS Metastatic Colorectal Cancer is a phase 2, interventional study registered as NCT05985109 by Peking University Cancer Hospital & Institute, with a registry enrolment figure of 98 participants, started 2023-10-26 and due to reach its primary completion in 2026-12-31. Interventions recorded: KN046; regorafenib. Conditions listed: Colorectal Cancer. Primary outcome: Overall response rate. Colorectal eligibility wording from the registry: "Histologically confirmed colorectal adenocarcinoma, including signet ring cell carcinoma and mucinous adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05985109
- Phase: 2
- Setting: A Phase II Multi-cohort Clinical Study Evaluating The Efficacy and Safety of KN046 in Combination With Regorafenib for Metastatic Microsatellite-Stable Colorectal Cancer: a Phase II Multi-cohort Study
- Sponsor: Peking University Cancer Hospital & Institute
- Enrolled: 98

## Sources

- ClinicalTrials.gov NCT05985109: https://clinicaltrials.gov/study/NCT05985109

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Regorafenib](https://onco.cc/drugs/regorafenib/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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