# Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A

Source: https://onco.cc/trials/nct05998122/  
OnCo record `nct05998122` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by The First Hospital of Jilin University, not yet recruiting.

## Summary

Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal Patients With Locally Advanced Rectal CancerPatients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study is a phase 2, interventional study registered as NCT05998122 by The First Hospital of Jilin University, with a registry enrolment figure of 45 participants, started 2023-09-01 and due to reach its primary completion in 2026-12-31. Interventions recorded: nCRT → (CapeOX+Sintilimab)×6 → Surgery/W&W. Conditions listed: Locally Advanced Rectal Cancer; Total Neoadjuvant Treatment; Anti-PD-1. Primary outcome: Complete response rate (CR). Colorectal eligibility wording from the registry: "Pathologically diagnosed rectal adenocarcinoma: differentiated into Grade 1-3, that is, high, medium, and poorly differentiated tubular adenocarcinoma; classified as pMMR/MSS". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05998122
- Phase: 2
- Setting: Total Neoadjuvant Chemoradiotherapy Plus Anti-PD-1 in Subperitoneal High-Risk or Very High-Risk Patients With Locally Advanced Rectal Cancer: A Prospective, Single Arm, Exploratory Study
- Sponsor: The First Hospital of Jilin University
- Enrolled: 45

## Sources

- ClinicalTrials.gov NCT05998122: https://clinicaltrials.gov/study/NCT05998122

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05998122.json