# Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC

Source: https://onco.cc/trials/nct06002789/  
OnCo record `nct06002789` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, now recruiting.

## Summary

Safety and Efficacy of PD-1 ± mFOLFOX6 Neoadjuvant Therapy in Local Advanced sMPCC is a phase 2, interventional study registered as NCT06002789 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 17 participants, started 2022-05-01 and due to reach its primary completion in 2027-09-01. Interventions recorded: MSI-H/MSS (dMMR/pMMR) mixed sMPCC: combination of mFOLFOX6+PD-1 monoclonal antibody neoadjuvant therapy; All-MSI-H (dMMR) sMPCC: single-drug PD-1 monoclonal antibody neoadjuvant therapy. Conditions listed: Multiple Cancer; Colorectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: "Histological confirmation of simultaneous multiple primary colorectal cancer (sMPCC);". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06002789
- Phase: 2
- Setting: Safety and Efficacy of PD-1 Monoclonal Antibody With or Without mFOLFOX6 Neoadjuvant Therapy in Patients With Local Advanced Deficient Mismatch Repair/Microsatellite Instability-high Synchronous Multiple Primary Colorectal Cancer (sMPCC)
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 17

## Sources

- ClinicalTrials.gov NCT06002789: https://clinicaltrials.gov/study/NCT06002789

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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