# Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct06030622/  
OnCo record `nct06030622` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of gemcitabine in pancreatic cancer, run by State University of New York - Downstate Medical Center, now recruiting.

## Summary

Phase 2A Pilot C3 Trial of Recurrent/Refractory Metastatic Advanced Pancreatic Cancer is a phase 1/2, interventional study registered as NCT06030622 by State University of New York - Downstate Medical Center, with a registry enrolment figure of 25 participants, started 2024-04-17 and due to reach its primary completion in 2028-12-01. Interventions recorded: Gemcitabine and C3 (Metformin, Simvastatin, and Digoxin); C3 (Metformin, Simvastatin, and Digoxin) only. Conditions listed: Pancreatic Cancer Metastatic. Primary outcome: Primary Outcome: Safety and tolerability. Pancreatic eligibility wording from the registry: "Subject ≥18 years with histologically confirmed pancreatic cancer". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: C3
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT06030622
- Phase: 1/2
- Setting: Phase 2A Pilot Trial of Metformin, Digoxin, Simvastatin (C3) in Combination With Gemcitabine in Subjects With Recurrent / Refractory Metastatic Advanced Pancreatic Cancer
- Sponsor: State University of New York - Downstate Medical Center
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT06030622: https://clinicaltrials.gov/study/NCT06030622

## Connected records

- cancers: [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Gemcitabine](https://onco.cc/drugs/gemcitabine/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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