# Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer

Source: https://onco.cc/trials/nct06047015/  
OnCo record `nct06047015` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by University of Saskatchewan, not yet recruiting.

## Summary

Irreversible Electroporation (NanoKnife ®) and Immunotherapy for the Treatment of Stage IV Colorectal Cancer is a phase 1/2, interventional study registered as NCT06047015 by University of Saskatchewan, with a registry enrolment figure of 12 participants, started 2025-07 and due to reach its primary completion in 2027-12. Interventions recorded: IRE plus checkpoint inhibitor; IRE plus Checkpoint Inhibitor plus CpG-ODN. Conditions listed: Liver Metastasis Colon Cancer. Primary outcome: Complications; Complications; Abscopal effect: percent change in non-treated colorectal liver metastasis.. Colorectal eligibility wording from the registry: "Biopsy-proven colorectal liver metastases with at least one measuring \< 3". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06047015
- Phase: 1/2
- Setting: Immune Response to Irreversible Electroporation (NanoKnife ®) and a Checkpoint Inhibitor With or Without CpG Oligodeoxynucleotides for the Treatment of Stage IV Colorectal Cancer
- Sponsor: University of Saskatchewan
- Enrolled: 12

## Sources

- ClinicalTrials.gov NCT06047015: https://clinicaltrials.gov/study/NCT06047015

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06047015.json