# Durvalumab with chemotherapy in high-risk early breast cancer

Source: https://onco.cc/trials/nct06058377/  
OnCo record `nct06058377` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This study compares usual chemotherapy with or without durvalumab in a selected high-risk group of early breast cancers. It asks whether adding immune treatment lowers the chance of a cancer-related event.

## Summary

This study compares usual chemotherapy with or without durvalumab in a selected high-risk group of early breast cancers. It asks whether adding immune treatment lowers the chance of a cancer-related event.

Interventional study registered as NCT06058377, sponsored by National Cancer Institute (NCI). Registry phase: 3. Registry enrollment is 3,680 participants (estimated). Registry status checked October 10, 2026: recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-10-10
- Also known as: Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT06058377
- Phase: 3
- Setting: Stage II to III hormone receptor-positive, HER2-negative breast cancer with MammaPrint High 2 risk
- Sponsor: National Cancer Institute (NCI)

## Sources

- ClinicalTrials.gov NCT06058377: https://clinicaltrials.gov/study/NCT06058377
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT06058377

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Durvalumab](https://onco.cc/drugs/durvalumab/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

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