# A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy 

Source: https://onco.cc/trials/nct06091254/  
OnCo record `nct06091254` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Odronextamab, Rituximab, Cyclophosphamide in follicular lymphoma, run by Regeneron Pharmaceuticals, now recruiting.

## Summary

A Trial to Learn if Odronextamab is Safe and Well-Tolerated and How Well it Works Compared to Rituximab Combined With Different Types of Chemotherapy for Adult Participants With Previously Untreated Follicular Lymphoma is a phase 3 interventional study registered as NCT06091254 by Regeneron Pharmaceuticals, with 822 participants planned, started 2023-12-12 and due to reach its primary completion in 2028-02-07. Interventions recorded: Odronextamab, Rituximab, Cyclophosphamide, Doxorubicin, Vincristine. Conditions listed: Follicular Lymphoma (FL). No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06091254
- Phase: 3
- Setting: A Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Odronextamab (REGN1979), an Anti-CD20 X Anti-CD3 Bispecific Antibody Versus Investigator's Choice in Previously Untreated Participants With Follicular Lymphoma (OLYMPIA-1)
- Sponsor: Regeneron Pharmaceuticals
- Enrolled: 822

## Sources

- ClinicalTrials.gov NCT06091254: https://clinicaltrials.gov/study/NCT06091254

## Connected records

- cancers: [Follicular lymphoma](https://onco.cc/cancers/follicular-lymphoma/)
- drugs: [Cyclophosphamide](https://onco.cc/drugs/cyclophosphamide/), [Doxorubicin](https://onco.cc/drugs/doxorubicin/), [Odronextamab](https://onco.cc/drugs/odronextamab/), [Prednisone](https://onco.cc/drugs/prednisone/), [Rituximab](https://onco.cc/drugs/rituximab/), [Vincristine](https://onco.cc/drugs/vincristine/)
- companies: [Regeneron](https://onco.cc/companies/regeneron/)

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