# Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer

Source: https://onco.cc/trials/nct06097416/  
OnCo record `nct06097416` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by St. James's Hospital, Ireland, not yet recruiting.

## Summary

Neoadjuvant Chemoradiotherapy Versus Total Neoadjuvant Therapy in the Treatment of T3 Rectal Cancer is a phase 3, randomised interventional study registered as NCT06097416 by St. James's Hospital, Ireland, with a registry enrolment figure of 100 participants, started 2024-10 and due to reach its primary completion in 2025-10. Interventions recorded: Neoadjuvant Chemoradiotherapy; Total Neoadjuvant Therapy. Conditions listed: Rectal Cancer. Primary outcome: Overall survival. Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed surgically resectable adenocarcinoma of the rectum". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06097416
- Phase: 3
- Setting: A Phase III, Multi-institutional Randomised Trial Comparing Neoadjuvant Chemoradiotherapy (NARCT) and Total Neoadjuvant Therapy (TNT) in Patients With T3 (a/b/c) Rectal Cancer
- Sponsor: St. James's Hospital, Ireland
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT06097416: https://clinicaltrials.gov/study/NCT06097416

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06097416.json