# Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents

Source: https://onco.cc/trials/nct06120491/  
OnCo record `nct06120491` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing Saruparib in prostate cancer, active and no longer recruiting.

## Summary

Saruparib (AZD5305) vs Placebo in Men With Metastatic Castration-Sensitive Prostate Cancer Receiving Physician's Choice New Hormonal Agents is a phase 3 interventional study registered as NCT06120491, led by AstraZeneca, and active but no longer recruiting on the registry. Official title: A Randomised, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01). Planned enrolment is 1898 participants (actual). The study started in 2023-11-21 and primary completion is expected in 2027-09-30. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-11
- Also known as: EvoPAR-Prostate01
- Tags: ctgov-ingest
- Registry id: NCT06120491
- Phase: 3
- Setting: A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)
- Sponsor: AstraZeneca
- Enrolled: 1898

## Sources

- ClinicalTrials.gov NCT06120491: https://clinicaltrials.gov/study/NCT06120491

## Connected records

- cancers: [Metastatic hormone-sensitive prostate cancer](https://onco.cc/cancers/prostate-mhspc/), [Prostate cancer](https://onco.cc/cancers/prostate/)
- drugs: [Saruparib](https://onco.cc/drugs/saruparib/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)

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JSON: https://onco.cc/api/v1/entities/nct06120491.json