# COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases

Source: https://onco.cc/trials/nct06185556/  
OnCo record `nct06185556` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Amsterdam UMC, location VUmc, now recruiting.

## Summary

COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases is a phase 2/3, randomised interventional study registered as NCT06185556 by Amsterdam UMC, location VUmc, with a registry enrolment figure of 78 participants, started 2024-08-20 and due to reach its primary completion in 2029-09-01. Interventions recorded: Irreversible electroporation; Stereotactic body radiotherapy. Conditions listed: Colorectal Cancer; Liver Metastases; Liver Metastasis Colon Cancer; Unresectable Solid Tumor. Primary outcome: Local control. Colorectal eligibility wording from the registry: "* Histological documentation of primary colorectal tumor is available;". Sites: Netherlands. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: COLDFIRE-III
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06185556
- Phase: 2/3
- Setting: COLDFIRE-III Trial: Perivascular and Peribiliary Colorectal Liver Metastases (0-5cm): Irreversible Electroporation Versus Stereotactic Body Radiotherapy
- Sponsor: Amsterdam UMC, location VUmc
- Enrolled: 78

## Sources

- ClinicalTrials.gov NCT06185556: https://clinicaltrials.gov/study/NCT06185556

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- companies: [AngioDynamics](https://onco.cc/companies/angiodynamics/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06185556.json