# A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With 

Source: https://onco.cc/trials/nct06188520/  
OnCo record `nct06188520` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Camizestrant, Ribociclib, Palbociclib in ovarian cancer, run by AstraZeneca, now recruiting.

## Summary

A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT06188520 by AstraZeneca, with 564 participants planned, started 2023-12-05 and due to reach its primary completion in 2027-08-04. Interventions recorded: AZD8421, Camizestrant, Ribociclib, Palbociclib, Abemaciclib. Conditions listed: ER+ HER2- Advanced Breast Cancer, High-grade Serous Ovarian Cancer (HGSOC). No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT06188520
- Phase: 1/2
- Setting: A Phase I/IIa, First-in-human, Open-label, Dose Escalation and Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors
- Sponsor: AstraZeneca
- Enrolled: 564

## Sources

- ClinicalTrials.gov NCT06188520: https://clinicaltrials.gov/study/NCT06188520

## Connected records

- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- drugs: [Abemaciclib](https://onco.cc/drugs/abemaciclib/), [AZD8421](https://onco.cc/drugs/azd8421/), [Camizestrant](https://onco.cc/drugs/camizestrant/), [Palbociclib](https://onco.cc/drugs/palbociclib/), [Ribociclib](https://onco.cc/drugs/ribociclib/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)

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JSON: https://onco.cc/api/v1/entities/nct06188520.json