# Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC

Source: https://onco.cc/trials/nct06195670/  
OnCo record `nct06195670` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by Zhejiang Cancer Hospital, not yet recruiting.

## Summary

Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine as First Line Treatment in Advanced mCRC is a phase 1/2, randomised interventional study registered as NCT06195670 by Zhejiang Cancer Hospital, with a registry enrolment figure of 220 participants, started 2024-01 and due to reach its primary completion in 2026-01. Interventions recorded: Experimental; Active Comparator. Conditions listed: CRC; Metastatic Colorectal Cancer; Metastatic Colorectal Adenocarcinoma. Primary outcome: Phase 1b - Objective Response Rate (ORR); Phase 2 - Progression-free Survival (PFS). Colorectal eligibility wording from the registry: "* Histopathologically confirmed unresectable advanced metastatic colorectal adenocarcinoma;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06195670
- Phase: 1/2
- Setting: An Open-label, Multi-centered, Two-stage Clinical Study of Short-course Radiotherapy Followed by Fruquintinib Plus Sintilimab vs Bevacizumab Plus Capecitabine in the First Line Treatment of Advanced mCRC Patients Unfit for Intense Therapy
- Sponsor: Zhejiang Cancer Hospital
- Enrolled: 220

## Sources

- ClinicalTrials.gov NCT06195670: https://clinicaltrials.gov/study/NCT06195670

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06195670.json