# Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer

Source: https://onco.cc/trials/nct06197425/  
OnCo record `nct06197425` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Centre Hospitalier Universitaire Dijon, now recruiting.

## Summary

Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer is a phase 3, randomised interventional study registered as NCT06197425 by Centre Hospitalier Universitaire Dijon, with a registry enrolment figure of 1660 participants, started 2026-05-07 and due to reach its primary completion in 2032-05. Interventions recorded: "FOLFIRI" cures; Trifluridine cures; BIOLOGICAL ASSESSMENT; Questionnaires; Thoracic-abdomino-pelvic scan or MRI. Conditions listed: Colon or Upper Rectum Adenocarcinoma. Primary outcome: The time to recurrence (TTR). Colorectal eligibility wording from the registry: "* Fully resected stage III or high-risk stage II colon or upper rectum adenocarcinoma previously treated by standard adjuvant chemotherapy or peri-operative chemotherapy (FOLFOX or CAPOX) for either 3 or 6 months based on local multidisciplinary meeting, and on TNCD recommendations". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CIRCULATE PAC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT06197425
- Phase: 3
- Setting: Phase III Multicentric, Open-label, Randomized Study to Investigate the Efficacy of Chemotherapy in Patients With Positive ctDNA After Surgery and Adjuvant Chemotherapy for a Stage III Colorectal Cancer (PRODIGE 88)
- Sponsor: Centre Hospitalier Universitaire Dijon
- Enrolled: 1660

## Sources

- ClinicalTrials.gov NCT06197425: https://clinicaltrials.gov/study/NCT06197425

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct06197425.json